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male c57bl 6j mice  (Jackson Laboratory)

 
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    Jackson Laboratory male c57bl 6j mice
    Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) <t>Male</t> <t>C57BL/6J</t> mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.
    Male C57bl 6j Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c57bl+6j+mice/pmc12816905-34-0-8?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    male c57bl 6j mice - by Bioz Stars, 2026-07
    86/100 stars

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    1) Product Images from "Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice"

    Article Title: Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

    Journal: Journal of Sport and Health Science

    doi: 10.1016/j.jshs.2025.101100

    Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) Male C57BL/6J mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.
    Figure Legend Snippet: Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) Male C57BL/6J mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.

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    Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) <t>Male</t> <t>C57BL/6J</t> mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.
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    Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) Male C57BL/6J mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.

    Journal: Journal of Sport and Health Science

    Article Title: Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

    doi: 10.1016/j.jshs.2025.101100

    Figure Lengend Snippet: Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) Male C57BL/6J mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.

    Article Snippet: Male C57BL/6J mice (8–10 weeks) were purchased from the Jackson Lab (Bar Harbor, ME, USA) and housed in the animal care facility under 12-h light and dark cycle standard conditions.

    Techniques:

    Incomplete oncologic surgery accelerates subsequent regrowth of residual tumors (A) Male C57BL/6J mice bearing TAO1 (murine sarcoma) tumors were subjected to no surgery, sham surgery, or incomplete resection where an estimated 50%, 75%, or 95% of the tumor was removed. Residual tumor growth was then measured by caliper. Sham tumors, exposed to systemic surgical trauma, experienced accelerated growth. Incompletely resected tumors regrew at an accelerated rate. n = 3–4 mice per group. Significance determined by one-way ANOVA, ∗ p < 0.05, ∗∗ p < 0.005, ∗∗∗ p < 0.0005.

    Journal: STAR Protocols

    Article Title: Protocol for incomplete murine tumor resection to study local effects of surgical trauma on residual sarcoma

    doi: 10.1016/j.xpro.2026.104481

    Figure Lengend Snippet: Incomplete oncologic surgery accelerates subsequent regrowth of residual tumors (A) Male C57BL/6J mice bearing TAO1 (murine sarcoma) tumors were subjected to no surgery, sham surgery, or incomplete resection where an estimated 50%, 75%, or 95% of the tumor was removed. Residual tumor growth was then measured by caliper. Sham tumors, exposed to systemic surgical trauma, experienced accelerated growth. Incompletely resected tumors regrew at an accelerated rate. n = 3–4 mice per group. Significance determined by one-way ANOVA, ∗ p < 0.05, ∗∗ p < 0.005, ∗∗∗ p < 0.0005.

    Article Snippet: C57BL/6J mice (male and female, 6–8 weeks old) , Jackson Labs , Strain# 000664; RRID: IMSR_JAX:000664.

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